aaaaaaaaa MolLife Design LLC » Gregory V. Nikiforovich - Cogito ergo sum
Gregory V. Nikiforovich                   COGITO  ERGO  SUM
        About Me
        Papers in Russian
MolLife Design LLC
LOG: Aug. 13, 2017

MolLife Design LLC was founded by me in 2008 following my retirement from the Washington University. The goal was (and still is) to perform scientific consulting in field of molecular modeling for investigators both in academia and in industry. That involves actual working on various projects collaborating with molecular biologists (studies of G-protein-coupled receptors) and peptide chemists (studies of intermolecular recognition). MolLife Design LLC operates in a research-for-fee business mode.

The modeling lab of MolLife Design LLC is located in separate space and accommodates three working places. The lab is equipped with a cluster of six Linux-based processors and three Window-based PCs, all of which are connected into a local network. The lab is equipped also with local and network printers and scanner. It has a high-speed Internet access and telephone. The adjacent space used for administrative purposes is equipped with another PC, telephone/fax, printer and facilities for presentations. 

Currently, MolLife Design is involved in consulting and collaboration with Dr. Thomas J. Baranski (Washington University, grant NIH R01 GM071634) and Dr. Ya-Xiong Tao (Auburn University, grant NIH R15 DK077213). Since beginning in 2008, these collaborations yielded the following publications:


Nikiforovich GV, Taylor CM., Marshall, GR, Baranski, TJ. Difference between restoring and predicting 3D structures of the loops in G-protein-coupled receptors by molecular modeling (Letter to Editor, published online) Proc. Natl. Acad. Sci. USA, 2011; doi/10.1073/pnas.1107702108 [PDF]

Ye Y, Xu B, Nikiforovich GV, Bloch S, Achilefu S. Exploring new near-infrared fluorescent disulfide-based cyclic RGD peptide analogs for potential integrin-targeted optical imaging. Bioorg. Medicinal Chem. Letters, 2011; 21: 2116-2120 [PDF]           

Nikiforovich GV, Taylor CM., Marshall, GR, Baranski, TJ. Simplified modeling approach suggests structural mechanisms for constitutive activation of the C5a receptor. Proteins: Structure, Function and Bioinformatics, 2011; 79: 787-802 [PDF]

Nikiforovich GV, Baranski TJ. Computational modeling of constitutively active mutants of GPCRs: C5a receptors. Methods in Enzymology, 2010; 485: 369-392 [

Tao Y-X, Huang H, Wang Z-Q, Yang F, Williams JN, Nikiforovich GV. Constitutive activity of neural melanocortin receptors, 2010, Methods in Enzymology, 2010; 484: 267-279 [

Nikiforovich GV, Taylor CM., Marshall, GR, Baranski, TJ. Modeling the possible conformations of the extracellular loops in G-Protein-coupled receptors. Proteins: Structure, Function and Bioinformatics, 2010; 78: 271-285 [PDF]

Nikiforovich, G.V., T.J. Baranski, Structural models for the complex of chemotaxis inhibitory protein of Staphylococcus aureus with the C5a receptor. Biochem. Biophys. Res. Commun., 2009; 390: 481-484 [PDF]

MolLife Design LLC is looking forward to further contacts aiming on fruitful collaborations with all interested parties. Please use contact information below.

Contact Information:
Dr. Gregory V. Nikiforovich
MolLife Design LLC 
751 Aramis Drive
St. Louis, MO 63141
Phone/fax: (314) 434-5089

  Copyright (c)2009 Gregory V. Nikiforovich&